Single Nucleotide Polymorphism in FTO rs9939609 and Obesity Among Asians and Caucasians: A Meta-Analysis
Harry F. Luglio and Dian C. Sulistyoningrum
Affiliation: Department of Health Nutrition, Universitas Gadjah Mada, Yogyakarta, Indonesia, Jl. Farmako, Sekip Utara, Yogyakarta, 55281, Indonesia.
Keywords: FTO, polymorphism, obesity, BMI, Asian, Caucasian.
Scope: FTO is now confirmed as the gene responsible for obesity but epidemiological studies showed various results
based on different locations in the gene and in which ethnic group the polymorphism was found. The objective of this
meta analysis was to contrast reports on FTO and obesity association among Asian and Caucasian ancestries. Methods
and Results: This study was done by a literature search from PUBMED using a combination of terms of “FTO”, “obesity”,
“BMI”, “weight” and “waist circumference” between January 2007 and February 2012. Observation studies were
collected from several countries in Europe and North America reflecting Caucasian ethnic group and countries in South,
East and South East Asia reflecting Asian ethnic group. FTO rs9939609 was the most studied loci. The minor allele frequency
(MAF) of A allele of rs9939609 in Asians (es=24.77; 95%CI=20.91-28.63; I2=60.79%) was lower as compared to
Caucasians (es=41.03; 95% CI=40.48-41.68; I2=0%). The OR for obesity of rs9939609 SNP was not different between
Asians (es=1.31; 95%CI=1.12-1.49; I2=0%) and Caucasians (es=1.27; 95%CI=1.18 - 1.36; I2=31.65%). Conclusion: Although
Caucasians have higher minor allele frequency (MAF) of FTO rs9939609 than Asians, the effect of this SNP on
obesity is similar. This might explain higher prevalence of obesity in Caucasians.
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