Recent Patents on Nanoceramics and Bone Regeneration and Repair
Rosemary Dziak, Laura Barres and Sebastiano Andreana
Affiliation: 302 Foster Hall, University at Buffalo, South Campus, Buffalo, NY 14212, USA.
Regeneration of bone lost through pathological and/or traumatic events is a complex process due to the intricate,
dynamic nature of the skeleton. Although osseous tissue has the ability in many circumstances to organize its own
regeneration, tissue engineering, particularly of large, critical size defects, can be optimized by clinical intervention. Products
have been developed to aid in the repair and regeneration of bone based on ever growing knowledge of the interactions
of bone cells with the extracellular matrix and mineral components. A number of recent patents have disclosed information
regarding the fabrication of nanostructured scaffolds that have the ability to support osteoconduction and how
these structures can be utilized in various bone regenerative aspects. Nanoceramics are central to the development of bone
tissue-engineered and recent patents address how nanohydroxyapatite, nanocalcium sulfate and other nanomaterials can be
utilized alone or as composites in combination with matrix-like polymers, angiogenic and growth factors as well as cells
to construct biocompatible implant materials to enhance bone growth.
Keywords: Bone regeneration, bone repair, nanoceramics, nanotechnology, scaffolds, tissue engineering.
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