Mass spectrometry (MS) analysis plays an important role in the structural elucidation of natural marine toxins. In MS analysis,
the chemical structural elucidation is mainly achieved by tandem MS (MS/MS) and multiple stage MS (MSn) techniques, in which fragmented
product ions are used to interpret precursor ion structures. Herein we discuss the MS/MS and MSn behaviors of major marine toxins,
such as domoic acid, anatoxins, saxitoxins, tetrodotoxins, okadaic acid, dinophysistoxins, azaspiracids, gymnodimines, spirolides,
pinnatoxins, brevetoxins, ciguatoxins, yessotoxins, brevisulcenal-F, palytoxins, and protein/peptide toxins like conotoxins. In this review,
our primal focus is on organization of literature data after 2000.