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Current Drug Delivery
ISSN (Print): 1567-2018
ISSN (Online): 1875-5704
Epub Full Text Article
DOI: 10.2174/1567201811666140515145329      Price:  $95









Physical Means of Stratum Corneum Barrier Manipulation to Enhance Transdermal Drug Delivery

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Author(s): Rabinarayan Parhi, Podilam Suresh and Suhasini Patnaik
Abstract:
Since the approval of first transdermal patch (Transderm Scop® ) containing scopolamine in 1979, the improvement in systemic drug delivery through skin remains incremental. The traditional methods based on passive diffusion of drug molecules in to the skin are unable to deliver macromolecules, such as peptides , proteins, DNA and vaccines, due to the barrier properties of stratum corneum (SC). During the course of approximately 35 years, the focuses are not only to overcome the above barrier property of the skin b ut also the safety , accuracy and patient compliance aspect of the traditional met hods. The former limitation can be overcome by altering the SC barrier function by different active methods such electrically assisted methods (sonophoresis, iontophoresis, electroporation, m agnetophoresis, p ressure waves, e lectron beam irradiation), SC abruption ( microneedles, high - velocity jet) and SC removal ( tape - stripping, suction, microde rmabrasion, a blation). This review summarizes basic principles, mechanisms, advantages, limitations and recent development of above physical techniques along with skin anatomy and drug transport pathways across skin
Keywords:
Bilipid layer, Cavitation, Microneedle, Permeation, Physical methods, Transdermal drug delivery, Stratum corneum
Affiliation:
Department of Pharmaceutics GITAM Institute of Pharmacy GITAM University Gandhi Nagar Campus Rushikonda Visakhapatnam- 530045 Andhra Pradesh India