Antidepressant Like Effects of Alternanthera sessilis and Clerodendrum infortunatum Leaves Extract in Immobility Models
Rajiv Gupta and Hemant K. Singh
Affiliation: School of Pharmacy, Babu Banarasi Das National Institute of Technology & Management (BBD University), BBD Green City, Faizabad Road, Lucknow-227 105, Uttar Pradesh, India.
The present study was aimed at assessing the anti-depressant activity of the alcoholic extracts of the leaves of
Alternanthera sessilis and Clerodendrum infortunatum. The activity was studied on Swiss Albino mice using the Tail
Suspension Test and the Forced Swim Test, at doses of 100mg/kg b.w. and 20 mg/kg b.w. with Diazepam as the standard
drug. Both the extracts, at higher dose, exhibited significant reduction in the duration of immobility. The alcoholic extract
of Clerodendrum infortunatum was the most active extract in both the animal models, at a dose of 200 mg/kg b.w. Thus
this study verifies the claims of antidepressant activity of these plants in the tradional medicine.
Keywords: Alternanthera sessilis, anti-depressant, clerodendrum infortunatum.
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