Letters in Organic Chemistry

Miguel Yus  
Universidad de Alicante Apdo
Alicante
Spain

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Synthesis of 3-substituted Coumarins: An Efficient Green Approach Using L-proline as Catalyst in Triethanolamine Medium

Author(s): Devulapally Srikrishna, Syed Tasqeeruddin and Pramod Kumar Dubey

Affiliation: Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad College of Engineering, Kukatpally, Hyderabad, India - 500085.

Keywords: Salicylaldehydes, active methylene compounds, L-proline, triethanolamine, coumarins, Knoevenagel condensation.

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Abstract:

3-Substituted coumarins were synthesized very efficiently, using Knoevenagel method from salicylaldehydes 1 and active methylene compounds 2 under green conditions. The effect of catalyst and solvent on this condensation was studied. L-proline was found to be the best catalyst and triethanolamine the best reaction medium for this reaction.

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Article Details

VOLUME: 11
ISSUE: 8
Page: [556 - 563]
Pages: 8
DOI: 10.2174/1570178611666140512215136