Synthesis of 3-substituted Coumarins: An Efficient Green Approach Using L-proline as Catalyst in Triethanolamine Medium
Devulapally Srikrishna, Syed Tasqeeruddin and Pramod Kumar Dubey
Affiliation: Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad College of Engineering, Kukatpally, Hyderabad, India - 500085.
3-Substituted coumarins were synthesized very efficiently, using Knoevenagel method from salicylaldehydes 1
and active methylene compounds 2 under green conditions. The effect of catalyst and solvent on this condensation was
studied. L-proline was found to be the best catalyst and triethanolamine the best reaction medium for this reaction.
Keywords: Salicylaldehydes, active methylene compounds, L-proline, triethanolamine, coumarins, Knoevenagel condensation.
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