The most prevalent skin infections are mainly caused by species of dermatophytes of the genera Trichophyton, Microsporum,
and Epidermophyton that infect keratinized tissues and stratum corneum of skin and hair. Besides proteases with
putative role of kinases and other enzymes, immune modulators are abundantly secreted during infection as well. The molecular
mechanism used by the dermatophytes to infect and counteract the host immune response is not well understood. The
defense against infections basically depends on the host's immune responses to metabolites of the fungi, virulence of the infecting
strain or species and anatomical site of the infection. The two aspects of the immune system, the immediate hypersensitivity
and delayed-type hypersensitivity against dermatophytes may be crucial to the progression and severity of skin infection.
Management of the infection through species identification and molecular diagnostic techniques as well as use of novel
targeted drugs in addition to conventional anti-fungal compounds is of great importance in dealing with disease onsets and
outbreaks. Here we reviewed the fungal skin infections elucidating their biologic and immunologic characteristics. Reaction
to fungal invasion by the infected epithelial tissue on the host side is also discussed. Moreover, determinants of protective
immunity and treatment options are focused that could confer long-lasting resistance to infection.
Keywords: Anti-dermatophyte proteins, dermatomycoses, immune response, therapeutic options in dermatomycoses.
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