Combinatorial Chemistry & High Throughput Screening

Rathnam Chaguturu 
iDDPartners, 3 Edith Court
Princeton Junction
NJ 08550


Chemometric Study of Retention Indices of Some Thiazolidinediones Derivatives in Two Low Polarity Stationary Phases

Author(s): Adam Smolinski and Tatjana Lj. Djakovic-Sekulic

Affiliation: Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, Novi Sad, Republic of Serbia.

Keywords: 5-arylidene-2, 4-thiazolidinediones, classification, color map, dendrogram, HCA, PCA.


Application of chemometric methods in the study of the retention indices of thirteen 5-arylidene-2,4- thiazolidinediones in two low polarity high-performance thin-layer chromatographic (HPTLC) stationary phases (RP-18 and RP-CN) and six aqueous mobile phases. Principal component analysis classified chromatographic systems into four specific groups while one system remained non-classified. Hierarchical clustering analysis enabled grouping of the chromatographic systems into three clusters, and the studied compounds into three main classes. The color map enabled more in-depth interpretation of the relationships between the studied compounds and HPTLC systems applied.

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Article Details

Page: [623 - 629]
Pages: 7
DOI: 10.2174/1386207317666140509102101