Combinatorial Chemistry & High Throughput Screening

Rathnam Chaguturu 
iDDPartners, 3 Edith Court
Princeton Junction
NJ 08550


Chemometric Study of Retention Indices of Some Thiazolidinediones Derivatives in Two Low Polarity Stationary Phases

Author(s): Adam Smolinski and Tatjana Lj. Djakovic-Sekulic

Affiliation: Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, Novi Sad, Republic of Serbia.


Application of chemometric methods in the study of the retention indices of thirteen 5-arylidene-2,4- thiazolidinediones in two low polarity high-performance thin-layer chromatographic (HPTLC) stationary phases (RP-18 and RP-CN) and six aqueous mobile phases. Principal component analysis classified chromatographic systems into four specific groups while one system remained non-classified. Hierarchical clustering analysis enabled grouping of the chromatographic systems into three clusters, and the studied compounds into three main classes. The color map enabled more in-depth interpretation of the relationships between the studied compounds and HPTLC systems applied.

Keywords: 5-arylidene-2, 4-thiazolidinediones, classification, color map, dendrogram, HCA, PCA.

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Article Details

Page: [623 - 629]
Pages: 7
DOI: 10.2174/1386207317666140509102101