Neurotrophic Factors for Retinal Ganglion Cell Neuropathy - With a Special Reference to Diabetic Neuropathy in the Retina
Guzel Bikbova, Toshiyuki Oshitari, Takayuki Baba and Shuichi Yamamoto
Affiliation: Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Chiba, Japan.
Keywords: Neurotrophic factor, retinal ganglion cell neuropathy, diabetes, neuroprotection.
Diabetes mellitus is a disease with a devastating impact on population. Recent data revealed that early retinal
neuropathy in patients with diabetic retinopathy involved a reduced expression of brain-derived neurotrophic factor. Retinal
ganglion cells (RGC) neuropathy is a progressive optic nerve neuropathy with RGC death and axonal degeneration,
and it leads to blindness in the elderly population worldwide. Thus, neuroprotective therapies that rescue damaged RGCs
and inhibit the progression of RGC loss and axonal degeneration are needed. This review introduces potential neuroprotective
therapies using different neurotrophic factors for damaged RGC in eyes with RGC neuropathy associated diseases.
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