Significance of Biotic Factors in Mesenchymal Stem Cell Fate in Regenerative Medicine
Rama Raju Baadhe,
Naveen Kumar Mekala,
Stem and progenitor cell research is a complex and exciting field which promises curative discoveries in numerous
areas including cancer, diabetes, and regenerative medicine. Use of biotic factors or growth factors has played an
essential role in the development of stem cell research. These biologically active components have been administered into
stem cells either to improve or maintain the stem cell proliferation, or to encourage controlled differentiation into more
defined cell types. Small molecules such as 6-Bromoindirubin-3´-oxime (BIO), cardiogenol-C, etc can help stem cell research
by controlling or influencing the regulatory changes in a controlled manner and to help understand the mechanisms
during stem cell differentiation. Extra cellular matrix (ECM) is another significant biotic factor, which mediates cell and
tissue behavior by influencing cell-matrix interactions. Thus, in this review we would like to emphasize significance of
various growth factors in stem cell research.
Keywords: 6-Bromoindirubin-3'-oxime (BIO), cardiogenol-C, hyaluronic acid, purmorphamine, small synthetic molecules,
vascular endothelial growth factor.
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