Medicinal Chemistry

Atta-ur-Rahman  
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: mc@benthamscience.org

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Functionalization of Tetracycline and Evaluation of Its Antibacterial Activity Including Against Resistant Bacteria

Author(s): Priyanka Dogra and Ghanshyam S. Chauhan

Affiliation: Department of Chemistry, Himachal Pradesh University, Summer Hill, Shimla-171 005 India.

Keywords: Acryloylation, antimicrobial polymers, lipase, resistant bacteria, tetracycline.

Graphical Abstract:


Abstract:

Ever growing resistance of pathogenic bacteria against the existing antibiotics has forced researchers to look for new methods and techniques to design effective antimicrobial agents. In the present study a new tetracycline-based antimicrobial polymer (AMP) was synthesized from tetracycline and methacrylic acid (MAAc) using lipase as catalyst. The AMP, thus obtained, was transformed into nanoparticles via an emulsion method. The AMP and its nano-form were characterized by FTIR, NMR, XRD, SEM and EDAX. The antibacterial activity of the AMP was studied against both resistant (-) [P. aeruginosa] and susceptible (+) [S. aureus] bacteria. The synthesized AMP, including its nanoform, was observed to be more potent and efficient antimicrobial agent than the precursor tetracycline.

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Article Details

VOLUME: 11
ISSUE: 1
Page: [86 - 93]
Pages: 8
DOI: 10.2174/1573406410666140507094435