Functionalization of Tetracycline and Evaluation of Its Antibacterial Activity Including Against Resistant Bacteria
Priyanka Dogra and Ghanshyam S. Chauhan
Affiliation: Department of Chemistry, Himachal Pradesh University, Summer Hill, Shimla-171 005 India.
Ever growing resistance of pathogenic bacteria against the existing antibiotics has forced researchers to look
for new methods and techniques to design effective antimicrobial agents. In the present study a new tetracycline-based antimicrobial
polymer (AMP) was synthesized from tetracycline and methacrylic acid (MAAc) using lipase as catalyst. The
AMP, thus obtained, was transformed into nanoparticles via an emulsion method. The AMP and its nano-form were characterized
by FTIR, NMR, XRD, SEM and EDAX. The antibacterial activity of the AMP was studied against both resistant
(-) [P. aeruginosa] and susceptible (+) [S. aureus] bacteria. The synthesized AMP, including its nanoform, was observed
to be more potent and efficient antimicrobial agent than the precursor tetracycline.
Keywords: Acryloylation, antimicrobial polymers, lipase, resistant bacteria, tetracycline.
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