Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Antimycobacterial Activity of Highly Functionalised Pyrrolothiazole Derivatives

Author(s): Abdulrahman I. Almansour, Venu Sanjeevi Lakshmipathi, Elumalai Manogaran, Mohamed Ashraf Ali, Farzana Beevi, Tan Soo Choon, Ang Chee Wei, Raju Suresh Kumar, Mohammad Asad.

Graphical Abstract:


Abstract:

A series of twelve pyrralothiazoles was synthesized using [3+2]- cycloaddition reactions. The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H37Rv and INH resistant M. tuberculosis strains using agar dilution method, four of them showed good activity with MIC of less than 1µM. Compound (4d) was found to be the most active with MIC of 0.231 µM and 4.372 µM respectively.

Keywords: [3+2]-cycloaddition, Antimycobacterial activity, Azomethine ylide, Dispiroheterocycle, Intermolecular.

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Article Details

VOLUME: 11
ISSUE: 8
Year: 2014
Page: [968 - 974]
Pages: 7
DOI: 10.2174/1570180811666140506204239
Price: $58