Synthesis and Antimycobacterial Activity of Highly Functionalised Pyrrolothiazole Derivatives
Abdulrahman I. Almansour, Venu Sanjeevi Lakshmipathi, Elumalai Manogaran, Mohamed Ashraf Ali, Farzana Beevi, Tan Soo Choon, Ang Chee Wei, Raju Suresh Kumar and Mohammad Asad
Affiliation: New Drug Discovery Research, Department of Medicinal Chemistry, Alwar Pharmacy College, Alwar, Rajasthan-301030, India.
A series of twelve pyrralothiazoles was synthesized using [3+2]- cycloaddition reactions. The synthesized
compounds were screened for their antimycobacterial activity against M. tuberculosis H37Rv and INH resistant M. tuberculosis
strains using agar dilution method, four of them showed good activity with MIC of less than 1µM. Compound (4d)
was found to be the most active with MIC of 0.231 µM and 4.372 µM respectively.
Keywords: [3+2]-cycloaddition, Antimycobacterial activity, Azomethine ylide, Dispiroheterocycle, Intermolecular.
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