Cardiovascular & Hematological Disorders-Drug Targets

(Formerly Current Drug Targets - Cardiovascular & Hematological Disorders)

Garry X. Shen  
University of Manitoba
Winnipeg, MB


Endothelial Cell Regulation of Cardiac Metabolism Following Diabetes

Author(s): Fang Wang, Dahai Zhang, Andrea Wan and Brian Rodrigues

Affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, B.C., Canada V6T 1Z3.

Keywords: Cardiomyopathy, fatty acids, heparanase, LPL, metabolism, VEGF.


The earliest change that occurs in the diabetic heart is reduced glucose consumption, with a switch to utilization of fatty acids (FA) predominantly as an energy resource. Although this adaptation might be beneficial in the short-term, over a protracted duration, it is potentially catastrophic given the malicious effects produced by high FA in cardiomyocytes. In this review, we describe how the endothelial cell (EC), a “first-responder” to hyperglycemia, communicates with the underlying cardiomyocyte. As this cross-talk is expected to facilitate increased FA delivery to, and utilization by, the cardiomyocyte, understanding this conversationshould assist in devising new therapeutic strategies to prevent or delay diabetic heart disease.

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Article Details

Page: [121 - 125]
Pages: 5
DOI: 10.2174/1871529X14666140505123221