Uncommon Becoming Common: Case Series of Primary Fallopian Tube Cancers
Kalpana Ragupathy, Neelam Dugar, Perviz Iqbal and Mohammed Alloub
Affiliation: Doncaster Royal Infirmary, No 22 Sandygate Grange Drive, Sheffield, S10 5NW, UK.
Keywords: Gynecological malignancy, PFTC, primary fallopian tube cancer.
Primary fallopian tube cancer (PFTC) is rare with an incidence of only 1% of gynaecology cancers. However,
reports are emerging that it might be more common than the historical figure. We retrospectively evaluated all women
diagnosed with fallopian cancers between November 2010 and October 2011. Incidence of fallopian cancers was 3.6%
(6/165) of gynaecological malignancies. 50% (n=3) presented with classical symptoms of pain and discharge. We
suspected PFTC in 3 out of the 6 cases (50%) while the figure quoted in literature is only 10%. While majority of women
with PFTC (>80%) have an elevated CA125 level, our cohort was different with only 2 among the 6 with raised CA125
levels. Primary surgery was done in 50% women (n=3) in our hospital while the rest were referred to tertiary gynaeoncology
centre. 3 (50%) have been diagnosed as having early stage disease and 3 (50%) as advanced cancer. Our case
series shows the difficulty in correlating clinic-radiological findings, misleading CA125 levels of PFTC, leading to
primary surgery being done by general gynaecologists rather than gyne-oncologists. A multi-disciplinary approach is
advised with low index of suspicion in postmenopausal women presenting with adnexal pain. We believe our cohort had a
higher rate of preoperative diagnosis because of the use of MRI in evaluation of adnexal masses.
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