Organoselenium Chemistry: Between Synthesis and Biochemistry

Indexed in: Book Citation Index, Science Edition, EBSCO.

The use of organoselenium reagents as catalysts is a common thread that runs through the chapters of this book, introducing important aspects of the modern organoselenium chemistry: organocatalysis, ...
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Selenium and “Bio-Logic” Catalysis: New Bioinspired Catalytic Reactions

Pp. 345-360 (16)

Caterina Tidei and Claudio Santi

Abstract

The discovery in the early sixties of the fundamental role that selenium plays in many living systems has led to investigate the chemical mechanisms of action of the most important selenoenzymes. These mechanisms together with the possibility to develop biomimetic molecules to be used as useful catalysts in green synthetic protocols will be explored in this chapter.

Keywords:

ROS, Antioxidant, Selenoenzymes, Oxidative stress, Glutathione Peroxidase, Prooxidants, Oxidation, Selenolate, Selenyl radical, EPR spectroscopy.

Affiliation:

Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1-06123 Perugia, Italy