Synthesis, Anticonvulsant and Antimicrobial Activities of Some New [1-(2-Naphthyl)-2-(pyrazol-1-yl)ethanone]oxime Ethers
Zeynep Ozdemir, Arzu Karakurt, Unsal Calis, Selami Gunal, Samil Isik, Z. Sibel Sahin and Sevim Dalkara
Affiliation: Inonu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 44280 Malatya, Turkey.
In this study, 12 new oxime ether derivatives, which were expected to show anticonvulsant and antimicrobial
activities, were synthesized. Oxime ether derivatives were synthesized by the reaction of various alkyl halides with 1-(2-
naphthyl)-2-(pyrazol-1-yl)ethanone oxime. Anticonvulsant activity of the compounds was determined by maximal electroshock
(MES) and subcutaneous metrazol (ScM) seizure tests, while neurological disorders were evaluated using rotorod
toxicity test according to the ASP of NIH. Compound 1, 6 and 7 showed anticonvulsant activity at 300 mg/kg dose
at 4 h, but compounds 1 and 7 showed toxicity at 300 mg/kg dose at half an hour. Antimicrobial activities of the compounds
were also determined using agar microdilution method. Compound 1 and 5 were found to have the highest antifungal
activity among the other compounds.
Keywords: (Arylalkyl)azole, pyrazole, oxime ether, anticonvulsant, antimicrobial, X-ray crystallography.
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