Medicinal Chemistry

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

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Synthesis, Anticonvulsant and Antimicrobial Activities of Some New [1-(2-Naphthyl)-2-(pyrazol-1-yl)ethanone]oxime Ethers

Author(s): Zeynep Ozdemir, Arzu Karakurt, Unsal Calis, Selami Gunal, Samil Isik, Z. Sibel Sahin, Sevim Dalkara.

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Abstract:

In this study, 12 new oxime ether derivatives, which were expected to show anticonvulsant and antimicrobial activities, were synthesized. Oxime ether derivatives were synthesized by the reaction of various alkyl halides with 1-(2- naphthyl)-2-(pyrazol-1-yl)ethanone oxime. Anticonvulsant activity of the compounds was determined by maximal electroshock (MES) and subcutaneous metrazol (ScM) seizure tests, while neurological disorders were evaluated using rotorod toxicity test according to the ASP of NIH. Compound 1, 6 and 7 showed anticonvulsant activity at 300 mg/kg dose at 4 h, but compounds 1 and 7 showed toxicity at 300 mg/kg dose at half an hour. Antimicrobial activities of the compounds were also determined using agar microdilution method. Compound 1 and 5 were found to have the highest antifungal activity among the other compounds.

Keywords: (Arylalkyl)azole, pyrazole, oxime ether, anticonvulsant, antimicrobial, X-ray crystallography.

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Article Details

VOLUME: 11
ISSUE: 1
Year: 2015
Page: [41 - 49]
Pages: 9
DOI: 10.2174/1573406410666140428150358
Price: $58