Medicinal Chemistry

Atta-ur-Rahman  
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: mc@benthamscience.org

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Synthesis, Anticonvulsant and Antimicrobial Activities of Some New [1-(2-Naphthyl)-2-(pyrazol-1-yl)ethanone]oxime Ethers

Author(s): Zeynep Ozdemir, Arzu Karakurt, Unsal Calis, Selami Gunal, Samil Isik, Z. Sibel Sahin and Sevim Dalkara

Affiliation: Inonu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 44280 Malatya, Turkey.

Keywords: (Arylalkyl)azole, pyrazole, oxime ether, anticonvulsant, antimicrobial, X-ray crystallography.

Graphical Abstract:


Abstract:

In this study, 12 new oxime ether derivatives, which were expected to show anticonvulsant and antimicrobial activities, were synthesized. Oxime ether derivatives were synthesized by the reaction of various alkyl halides with 1-(2- naphthyl)-2-(pyrazol-1-yl)ethanone oxime. Anticonvulsant activity of the compounds was determined by maximal electroshock (MES) and subcutaneous metrazol (ScM) seizure tests, while neurological disorders were evaluated using rotorod toxicity test according to the ASP of NIH. Compound 1, 6 and 7 showed anticonvulsant activity at 300 mg/kg dose at 4 h, but compounds 1 and 7 showed toxicity at 300 mg/kg dose at half an hour. Antimicrobial activities of the compounds were also determined using agar microdilution method. Compound 1 and 5 were found to have the highest antifungal activity among the other compounds.

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Article Details

VOLUME: 11
ISSUE: 1
Page: [41 - 49]
Pages: 9
DOI: 10.2174/1573406410666140428150358