Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

Back

Translate in Chinese

Progress of In Vivo Electroporation in the Rodent Brain

Author(s): Xue-Feng Ding, De-Lin Ma, Qiang Zhang, Wei Peng, Ming Fan and William Z. Suo

Affiliation: Department of Cognitive sciences, Beijing Institute of Basic Medical Sciences, Tai ping Road 27, Beijing 100850, P. R. China.

Keywords: Bilateral electroporation, brain disorder, gene therapy, in vivo electroporation, rodent brain.

Abstract:

In vivo electroporation is one of the most efficient methods for introducing the nucleic acids into the target tissues, and thus plays a pivotal role in gene therapeutic studies. In vivo electroporation in rodent brains is often involved in injection of nucleic acids into the brain ventricle or specific area and then applying appropriate electrical field to the correct area. Better understanding of the progress of electroporation in rodent brain may further facilitate gene therapeutic studies on some brain disorders. For this purpose, we briefly summarized the advantages, the procedures and recent progress of transferring nucleic acids into the rodent brain using in vivo electroporation.

Reprint ePrint Rights & PermissionsPrintExport

Article Details

VOLUME: 14
ISSUE: 3
Page: [211 - 217]
Pages: 7
DOI: 10.2174/1566523214666140424145305