Enantioselective Hydrogenation Catalyzed by Chiral Nanoporous Materials
Xiaohong Li and Peng Wu
Affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Rd., Shanghai 200062, China.
The recent progress, particularly in this decade, in enantioselective hydrogenation using nanoporous materials
supported catalysts was reviewed. The main content consists of the enantioselective hydrogenation or asymmetric
transfer hydrogenation of prochiral carbonyl compounds or other prochiral substrates containing C=C or C=N double
bonds using the immobilized chiral metal complex catalysts onto nanoporous materials, and the enantioselective hydrogenation
of prochiral carbonyl compounds using nanoporous materials supported noble metal nanoparticles/clusters after chirally modified
with cinchona alkaloids or other chiral molecules. The nanoporous materials discussed in this review involve ordered mesoporous
silicates or aluminosilicates, alumina-mesoporous silica composites, nanoporous carbons, periodic mesoporous resols and metal-organic
frameworks. Many examples about the enantioselective hydrogenation using nanoporous materials supported catalysts show that the
enantioselectivities are similar to or even higher when compared with the corresponding homogeneous counterparts. In particular, the
heterogenization of well-established soluble transition metal-based asymmetric catalysts on inorganic oxide or polymer supports allows
easy separation and hence recycling and reuse of these expensive asymmetric catalysts. Nanoporous materials supported noble metal
nanoparticles/clusters are also efficient in the relevant asymmetric hydrogenation reactions.
Keywords: Enantioselective, Heterogeneous, Hydrogenation, Metal complex, Nanoporous materials, Noble metal nanoparticles.
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