Letters in Drug Design & Discovery

Atta-ur-Rahman  , FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: lddd@benthamscience.org

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Synthesis and Antifungal Activity of 1,2,3-thiadiazole Derivatives Containing 1,3,4-thiadiazole Moiety

Author(s): Shui-Lin Yan, Ming-Yan Yang, Zhao-Hui Sun, Li-Jing Min, Cheng-Xia Tan, Jian-Quan Weng, Hong-Ke Wu and Xing-Hai Liu

Affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, China.

Keywords: 1, 2, 3-thiadiazole, 1, 3, 4-thiadiazole, Antifungal activity, Synthesis.

Graphical Abstract:


Abstract:

A series of 4-methyl-N-(5-substituted-1, 3,4-thiadiazol-2-yl)-1,2,3-thiadiazole-5-carboxamide 6a~6j. The chemical structures were confirmed by 1H NMR, FTIR, MS, and elemental analysis. All the compounds were investigated for antifungal activity. The antifungal activity results indicated that compound 6a exhibited good activities against C. arachidicola. It can be compared with the commercial drug. The compounds 6e, 6f, 6i, 6j exhibited moderate activity.

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Article Details

VOLUME: 11
ISSUE: 7
Page: [940 - 943]
Pages: 4
DOI: 10.2174/1570180811666140423222141