(+)-Lentiginosine, a natural trans-1,2-dihydroxyindolizidine belonging to the class of iminosugars, is a potent
inhibitor of amyloglucosidase, and a good inhibitor of Hsp90. The non-natural enantiomer, (–)-lentiginosine, induces
apoptosis on tumor cells of different origin and is poorly cytotoxic towards non-transformed cells. The significant biological
activity of these compounds has resulted in the development of many synthetic approaches for their preparation. This
review is an update of a previous survey and summarizes the most recent achievements on biological studies as well as total
syntheses of lentiginosine and trans-1,2-dihydroxyindolizidine analogues.
Keywords: Alkaloids, apoptosis, azaheterocycles, glycosidase inhibitors, hydroxyindolizidines, iminosugars, organic syntheses.
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