Enantioselective Synthesis of PPAR (Peroxisome Proliferator-Activated Receptors) Agonists and Antagonists
Pilar Goya, Ruth Perez-Fernandez, Rosario Gonzalez-Muniz and Jose Elguero
Affiliation: Instituto de Quimica Medica, Juan de la Cierva 3, 28006 Madrid, Spain.
Keywords: PPAR, enantioselective separation, enantioselective synthesis, Evans' chiral auxiliary, asymmetric hydrogenation,
chiral HPLC, chiral salts.
This review deals with stereoselective issues in PPAR ligands some of which are in clinical use for treating certain
metabolic disorders. After a short introduction of these nuclear receptor and their agonists, some cases of enantioselective
separations are reported. The main part concerns stereoselective synthesis first starting with asymmetric synthesis
from chiral precursors followed by what we refer to as “true” enantioselective methods. Some examples are discussed in
detail for each particular heading.
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