Current Topics in Medicinal Chemistry

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

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Enantioselective Synthesis of PPAR (Peroxisome Proliferator-Activated Receptors) Agonists and Antagonists

Author(s): Pilar Goya, Ruth Perez-Fernandez, Rosario Gonzalez-Muniz and Jose Elguero

Affiliation: Instituto de Quimica Medica, Juan de la Cierva 3, 28006 Madrid, Spain.

Keywords: PPAR, enantioselective separation, enantioselective synthesis, Evans' chiral auxiliary, asymmetric hydrogenation, chiral HPLC, chiral salts.

Graphical Abstract:


Abstract:

This review deals with stereoselective issues in PPAR ligands some of which are in clinical use for treating certain metabolic disorders. After a short introduction of these nuclear receptor and their agonists, some cases of enantioselective separations are reported. The main part concerns stereoselective synthesis first starting with asymmetric synthesis from chiral precursors followed by what we refer to as “true” enantioselective methods. Some examples are discussed in detail for each particular heading.

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Article Details

VOLUME: 14
ISSUE: 10
Page: [1283 - 1293]
Pages: 11
DOI: 10.2174/1568026614666140423112822