Current Topics in Medicinal Chemistry

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

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Asymmetric 1,3-Dipolar Cycloadditons of Stabilized Azomethine Ylides with Nitroalkenes

Author(s): Carmen Nejera and Jose M. Sansano

Affiliation: Departamento de Quimica Organica and Instituto de Sintesis Organica (ISO). Universidad de Alicante, E-03080-Alicante, Spain.

Keywords: Antitumoral, asymmetric synthesis, catalysis, cycloaddition, metal, organocatalyst.

Graphical Abstract:


Abstract:

This review highlights the biological importance of many polysubstituted nitro-prolines and -pyrrolidines. Their preparation using asymmetric 1,3-dipolar cycloadditions of azomethine ylides with nitroalkenes using diastereoselective and enantioselective strategies is described remarking the scope and main features of each one.

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Article Details

VOLUME: 14
ISSUE: 10
Page: [1271 - 1282]
Pages: 12
DOI: 10.2174/1568026614666140423112145