Asymmetric 1,3-Dipolar Cycloadditons of Stabilized Azomethine Ylides with Nitroalkenes

Author(s): Carmen Nejera, Jose M. Sansano.

Journal Name: Current Topics in Medicinal Chemistry

Volume 14 , Issue 10 , 2014

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Graphical Abstract:


This review highlights the biological importance of many polysubstituted nitro-prolines and -pyrrolidines. Their preparation using asymmetric 1,3-dipolar cycloadditions of azomethine ylides with nitroalkenes using diastereoselective and enantioselective strategies is described remarking the scope and main features of each one.

Keywords: Antitumoral, asymmetric synthesis, catalysis, cycloaddition, metal, organocatalyst.

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Article Details

Year: 2014
Page: [1271 - 1282]
Pages: 12
DOI: 10.2174/1568026614666140423112145
Price: $58

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