Thiazoline and thiazole heterocycles are privileged motifs found in numerous peptide-derived natural products
of biological interest. During the last decades, the synthesis of optically pure building blocks has been addressed by numerous
groups, which have developed a plethora of strategies to that end. Efficient and reliable methodologies that are
compatible with the intricate and capricious architectures of natural products are a must to further develop their science.
Structure confirmation, structure-activity relationship studies and industrial production are fields of paramount importance
that require these robust methodologies in order to successfully bring natural products into the clinic. Today’s chemist
toolbox is assorted with many powerful methods for chiral thiazoline and thiazole synthesis. Ranging from biomimetic
approaches to stereoselective alkylations, one is likely to find a suitable method for their needs.
Keywords: Antibiotics, chiral building blocks, peptides, thiazoles, thiazolines, thiopeptides.
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