Current Topics in Medicinal Chemistry

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

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Enantioselective Synthesis in Carbohydrate-Based Drug Discovery: Imino Sugars, Alkaloids and Macrolide Antibiotics

Author(s): Nuno M. Xavier and Amélia P. Rauter

Affiliation: Centro de Quimica e Bioquimica, Faculdade de Ciencias, Universidade de Lisboa, Campo Grande, Edificio C8, 5º Piso, 1749-016 Lisboa, Portugal.

Keywords: Alkaloids, carbohydrates, enantioselective synthesis, imino sugars, macrolide glycosides.

Graphical Abstract:


Abstract:

This review is dedicated to enantioselective methods for the generation of carbohydrate-based lead compounds for drug research. Selected examples encompassing imino sugars, bicyclic imino sugar-type alkaloids such as castanospermine, swainsonine, or alexine, as well as macrolide glycosides are covered and discussed.

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Article Details

VOLUME: 14
ISSUE: 10
Page: [1235 - 1243]
Pages: 9
DOI: 10.2174/1568026614666140423103848