Conformational Preferences of Chiral Acyclic Homooligomeric β2,2-Peptides

Author(s): Fernando Rodriguez, Francisco Corzana, Alberto Avenoza, Jesus Hector Busto, Jesus Manuel Peregrina, Maria del Mar Zurbano.

Journal Name:Current Topics in Medicinal Chemistry

Volume 14 , Issue 10 , 2014

Graphical Abstract:


Abstract:

α-Methylisoserine, a chiral acyclic quaternary β-amino acid, has been used to mimic secondary structures, when it is incorporated in a homogeneous β2,2-dipeptide. In particular, the observed folded conformations in aqueous solution can be regarded as mimics of β-turn.

Keywords: β-Peptides, conformational analysis, molecular dynamics, nuclear magnetic resonance.

Rights & PermissionsPrintExport

Article Details

VOLUME: 14
ISSUE: 10
Year: 2014
Page: [1225 - 1234]
Pages: 10
DOI: 10.2174/1568026614666140423101226
Price: $58

Article Metrics

PDF: 11
HTML: 0
EPUB: 0
PRC: 0