Current Topics in Medicinal Chemistry

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

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Conformational Preferences of Chiral Acyclic Homooligomeric β2,2-Peptides

Author(s): Fernando Rodriguez, Francisco Corzana, Alberto Avenoza, Jesus Hector Busto, Jesus Manuel Peregrina and Maria del Mar Zurbano

Affiliation: Departamento de Quimica, Universidad de La Rioja, Centro de Investigacion en Sintesis Quimica, C/ Madre de Dios, 51. 26006 Logrono (La Rioja). Spain.

Keywords: β-Peptides, conformational analysis, molecular dynamics, nuclear magnetic resonance.

Graphical Abstract:


Abstract:

α-Methylisoserine, a chiral acyclic quaternary β-amino acid, has been used to mimic secondary structures, when it is incorporated in a homogeneous β2,2-dipeptide. In particular, the observed folded conformations in aqueous solution can be regarded as mimics of β-turn.

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Article Details

VOLUME: 14
ISSUE: 10
Page: [1225 - 1234]
Pages: 10
DOI: 10.2174/1568026614666140423101226