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Current Topics in Medicinal Chemistry
ISSN (Print): 1568-0266
ISSN (Online): 1873-5294
VOLUME: 14
ISSUE: 10
DOI: 10.2174/1568026614666140423095331      Price:  $58









Recent Advances on the Enantioselective Synthesis of C-Nucleosides Inhibitors of Inosine Monophosphate Dehydrogenase (IMPDH)

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Author(s): Pedro Merino, Mattia Ghirardello, Tomas Tejero, Ignacio Delso and Rosa Matute
Pages 1212-1224 (13)
Abstract:
This review will describe the recent advances in the synthesis of C-nucleosides with inhibitory activity of inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the biosynthesis of guanine nucleotides. The review will cover synthetic approaches of structural analogues showing modifications in the furanose ring as well as in the heterocyclic base. Heterocyclic sugar nucleoside analogues in which the furanose ring has been replaced by a different heterocyclic ring including aza analogues, thioanalogues as well as dioxolanyl and isoxazolidinyl analogues are also considered.
Graphical Abstract:
Keywords:
C-Nucleosides, enzyme inhibitors, heterocyclic nucleosides, IMPDH, thiazole, tiazofurin.
Affiliation:
Laboratorio de Sintesis Asimetrica. Departamento de Sintesis y Estructura de Biomoleculas. ISQCH. Universidad de Zaragoza. CSIC. Campus San Francisco. Zaragoza, Aragon, Spain.