Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents)

Ryuichi Morishita  
School of Medicine
Osaka University


Evaluation of ANA-related Serologic Autoantibodies in Polycystic Ovary Syndrome

Author(s): Bahareh Hamedi, Eskandar K. Sarvestani, Azadeh Khalili, Mahboobeh B. Fard, Saeed Alborzi, Sara Davoodi, Mohammad A. Nazarinia.


Objectives: To evaluate the serum levels of common autoimmune parameters in women with polycystic ovary syndrome (PCOS) and compare with the control group. Design: prospective case-control study. Setting: Academic research institution. Patients: 102 women with PCOS and 100 healthy controls. Interventions: Questionnaire, physical examination, sonography, blood sampling. Main outcome measure(s): Serum levels of Anti Ds-DNA, Anti SS-A, Anti SS-B, Anti Sm, Anti RNP/sm, Anti Scl70and Anti jo-1 were evaluated in PCOS patients and control group by enzyme immunoassays. Results: No significant differences were detected between cases and controls in the level of antibodies and in the correlation between Biochemical markers (FSH, LH, TSH, Prolactin, Testosterone and DHEAS). Only higher scores of hirsutism showed a statistically significant correlation with Anti sm Ab. Conclusion: Our study showed that serologic markers of autoimmunity (Anti ds-DNA & ANAs) are not elevated in PCOS patients. However, severity of hirsutism was found to have a statistically significant correlation with anti sm Ab, so maybe with repeat to these tests in future trials, the exact relationship will be revealed.

Keywords: ANA antibodies, auto immune disorders, hirsutism, hyperandrogenism, menstrual abnormality, ovarian dysfunction, polycystic ovary syndrome, serologic markers.

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Article Details

Year: 2014
Page: [21 - 25]
Pages: 5
DOI: 10.2174/1871522214666140422234234