An Overview of Recent Patents on Nanosuspension
Nirav Modh, Dharmik Mehta, Punit Parejiya, Amirali Popat and Bhavesh Barot
Affiliation: Regulatory Affairs, Astron Research Ltd., Premier House, Opp. Gurudwara, S.G Highway, Bodakdev, Ahmedabad -380054, Gujarat, India.
Pharmaceutical scientists involved in drug discovery and drug development are facing serious problems with
newer poorly water soluble drugs with respect to their dissolution and bioavailability. Reducing the particle size of active
pharmaceutical ingredient has been an efficient and reliable method for improving the bioavailability of insoluble drugs.
Nanosuspension has emerged as an efficient and promising strategy for delivery of insoluble drugs due to its unique
advantages such as ease of modification, process flexibility, targeting capabilities, altered pharmacokinetic profile leading
to safety and efficacy. These unique features of nanosuspension have enabled its use in various dosage forms, including
specialized delivery systems such as oral, parenteral, peroral, ocular and pulmonary routes. Currently, efforts are being
directed to extend their applications in site-specific drug delivery. Large numbers of products based on nanosuspension
are in the market and few are under clinical trials. The commercialization potential of nanosuspension based formulation
for oral route is well established and products for other routes will enter the market within short span. Among the various
techniques available, only wet milling technique has been successfully used for commercial production of nanosuspension.
Nanosuspension based patents have extensive potential of reaching faster in the market as compared to other nanotechnology
based formulations. This review covers various aspects of techniques of preparation, route of administration and
commercialization of nanosuspension with main focus on the recent patents granted in the field.
Keywords: Bioavailability, commercialization, drug delivery, method of preparation, nanosuspension, nanotechnology, patents,
route of administration.
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