The presence of small amounts of circulating DNA in plasma was demonstrated 60 years ago. Since then, cellfree
DNA has been tested for quantity, fragmentation pattern and tumor-specific sequences in patients with various malignancies.
The introduction of improved detection methods showed that all these alterations are regularly detectable in many
cancer patients and the investigation of cell-free DNA may provide useful diagnostic and prognostic information. Herein,
we review the recent findings on cell-free DNA alterations in patients with prostate cancer and discuss its diagnostic and
Keywords: Prostate cancer, DNA fragmentation, cell-free DNA, DNA methylation, allelic imbalance.
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