Diagnostic und Therapeutic Value of Cell-free Circulating DNA as a Non-invasive Biomarker in Patients with Prostate Cancer
Stefan Latz, Stefan C. Muller and Jorg Ellinger
Affiliation: Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Sigmund-Freud- Strasse 25, 53105 Bonn, Germany.
Keywords: Prostate cancer, DNA fragmentation, cell-free DNA, DNA methylation, allelic imbalance.
The presence of small amounts of circulating DNA in plasma was demonstrated 60 years ago. Since then, cellfree
DNA has been tested for quantity, fragmentation pattern and tumor-specific sequences in patients with various malignancies.
The introduction of improved detection methods showed that all these alterations are regularly detectable in many
cancer patients and the investigation of cell-free DNA may provide useful diagnostic and prognostic information. Herein,
we review the recent findings on cell-free DNA alterations in patients with prostate cancer and discuss its diagnostic and
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