Current Cancer Therapy Reviews

Kurt S. Zaenker
Institute of Immunology and Experimental Oncology University Witten/Herdecke
Stockumerstraße 10, 58448 Witten
Germany

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Diagnostic und Therapeutic Value of Cell-free Circulating DNA as a Non-invasive Biomarker in Patients with Prostate Cancer

Author(s): Stefan Latz, Stefan C. Muller and Jorg Ellinger

Affiliation: Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Sigmund-Freud- Strasse 25, 53105 Bonn, Germany.

Keywords: Prostate cancer, DNA fragmentation, cell-free DNA, DNA methylation, allelic imbalance.

Abstract:

The presence of small amounts of circulating DNA in plasma was demonstrated 60 years ago. Since then, cellfree DNA has been tested for quantity, fragmentation pattern and tumor-specific sequences in patients with various malignancies. The introduction of improved detection methods showed that all these alterations are regularly detectable in many cancer patients and the investigation of cell-free DNA may provide useful diagnostic and prognostic information. Herein, we review the recent findings on cell-free DNA alterations in patients with prostate cancer and discuss its diagnostic and prognostic potential.

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Article Details

VOLUME: 9
ISSUE: 4
Page: [258 - 264]
Pages: 7
DOI: 10.2174/157339470904140418094329