Current Catalysis

Shaobin Wang  
Curtin University
Perth, WA 6845 U1987
Australia

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Deep Eutectic Mixture Catalyzed One-Pot Three-Component Synthesis of 1H-pyrazolo and 2H-indazolo Phthalazines

Author(s): Atul Chaskar

Affiliation: Department of Dyestuff Technology, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai - 400 019, India.

Keywords: Aldehydes, aqueous medium, deep eutectic mixture, 2, 3-dihydrophthalazine-1, 4-dione, 5, 5-dimethylcyclohexane- 1, 3-dione, ethylcyanoacetate, malononitrile.

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Abstract:

A direct, simple and green protocol describes synthesis of 1H-pyrazolo[1,2-b] phthalazine-5,10-diones and 2Hindazolo[ 2,1-b] phthalazine-triones derivatives using deep eutectic mixture (choline chloride: malonic acid) as a homogeneous catalyst as well as solvent at reflux temperature. This method provides significant advantages such as short reaction time, easy workup, and high yield of product, atom economy and recyclability of catalyst.

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Article Details

VOLUME: 3
ISSUE: 3
Page: [266 - 273]
Pages: 8
DOI: 10.2174/2211544703666140417230832