Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Oral Chemotherapy in Elderly Women with Metastatic Breast Cancer

Author(s): M.J. Molina-Garrido, A. Mora-Rufete and C. Guillen-Ponce

Affiliation: Consulta de Cancer en el Anciano, Seccion de Oncologia Medica, Hospital General Virgen de la Luz in Cuenca, Hermandad Donantes de Sangre Street. Cuenca. Spain.

Keywords: Breast cancer, decision-making, elderly, epidemiology, functional status, hormonal receptor status, instrumental activities of daily living, monotherapy, oral chemotherapy, quality of life.

Abstract:

Life expectancy has significantly increased over the past 30 years, with a greater prevalence of diverse disease states, especially cancer. As older persons are a very heterogeneous group with an increased prevalence of comorbidities and a relative inability to tolerate the adverse effects of chemotherapy, the treatment of cancer in the elderly is particularly demanding.

The principles of its management are similar to those in younger patients but with special considerations linked to comorbidities and clinical status. The objective of chemotherapeutic treatment in metastatic breast cancer has historically been primarily palliative.

The introduction of newer approaches with improved or at least equivalent efficacy and reduced toxicity is highly desirable. Such approaches may include the use of less toxic drugs, more convenient routes of administration (e.g., oral) and home-based (outpatient) rather than hospital-based therapies. The available oral cytostatic drugs include vinorelbine and capecitabine. In this review, we analyze oral cytostatic drugs in the elderly patient diagnosed with metastatic breast cancer.

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Article Details

VOLUME: 14
ISSUE: 5
Page: [665 - 672]
Pages: 8
DOI: 10.2174/1871520614666140416103440