Abstract
P2Y12 inhibitors constitute an essential part of the antithrombotic treatment, with proven clinical benefit in acute coronary syndromes and after percutaneous coronary interventions. Substantial evidence has emerged that, apart from their primary antiplatelet action, P2Y12 receptor inhibitors exhibit several off-target effects. In this review, we present the supporting evidence of P2Y12 inhibitors’ pleiotropic actions, discuss their clinical implications and underscore the necessity for further research on this issue.
Keywords: Clopidogrel, off-target effects, pleiotropic, P2Y12 inhibitors, prasugrel, ticagrelor.
Current Pharmaceutical Design
Title:Pleiotropic Effects of Platelet P2Y12 Receptor Inhibitors: Fact or Fiction?
Volume: 20 Issue: 28
Author(s): Athanasios Moulias, Ioanna Xanthopoulou and Dimitrios Alexopoulos
Affiliation:
Keywords: Clopidogrel, off-target effects, pleiotropic, P2Y12 inhibitors, prasugrel, ticagrelor.
Abstract: P2Y12 inhibitors constitute an essential part of the antithrombotic treatment, with proven clinical benefit in acute coronary syndromes and after percutaneous coronary interventions. Substantial evidence has emerged that, apart from their primary antiplatelet action, P2Y12 receptor inhibitors exhibit several off-target effects. In this review, we present the supporting evidence of P2Y12 inhibitors’ pleiotropic actions, discuss their clinical implications and underscore the necessity for further research on this issue.
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Cite this article as:
Moulias Athanasios, Xanthopoulou Ioanna and Alexopoulos Dimitrios, Pleiotropic Effects of Platelet P2Y12 Receptor Inhibitors: Fact or Fiction?, Current Pharmaceutical Design 2014; 20 (28) . https://dx.doi.org/10.2174/1381612820666140414211543
DOI https://dx.doi.org/10.2174/1381612820666140414211543 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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