G-Protein Coupled Receptor 124 (GPR124) in Endothelial Cells Regulates Vascular Endothelial Growth Factor (VEGF)-Induced Tumor Angiogenesis
G protein-coupled receptor 124 (GPR124; also called tumor endothelial marker 5, TEM5) is highly
expressed in tumor vasculature. While recent studies have revealed a role in vasculogenesis, evidence for
GPR124 function in tumor angiogenesis is lacking. Here, we demonstrate that GPR124 is required for VEGFinduced
tumor angiogenesis. GPR124 silencing in human endothelial cells inhibited mouse xenograft tumor
angiogenic vessel formation and tumor growth. GPR124 regulated VEGF-induced tumor angiogenic processes
in vitro including cell-cell interaction, permeability, migration, invasion, and tube formation. Therefore, GPR124
plays a key role in VEGF-induced tumor angiogenesis.
Keywords: Angiogenesis, cancer, G protein coupled receptors (GPCR), tumor, vascular biology, vascular
endothelial growth factor (VEGF).
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