Antibiotic Releasing Biodegradable Scaffolds for Osteomyelitis

Author(s): Manitha Nair, Amit Krishnan.

Journal Name:Current Drug Delivery

Volume 11 , Issue 6 , 2014

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Abstract:

Osteomyelitis is characterized by progressive inflammatory bone degeneration. In the management of chronic osteomyelitis, it is necessary to remove the infected bone tissue followed by implantation of an antibiotic releasing biomaterial that can release antibiotic locally for long periods of time. The main carrier used in clinics for this application is polymethylmethacrylate (PMMA) (Eg. Septopal beads). However, major drawback is the need of an additional surgery to remove the beads after therapy, as PMMA is not biodegradable. This necessitates the requirement of biodegradable carrier systems that can release antibiotics and simultaneously support debrided bone formation. This review summarizes biodegradable carrier systems that have been reported for the localised treatment and prophylaxis of osteomyelitis.

Keywords: Bacterial internalization, biodegradable scaffolds, osteomyelitis, staphylococcus aureus.

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Article Details

VOLUME: 11
ISSUE: 6
Year: 2014
Page: [687 - 700]
Pages: 14
DOI: 10.2174/1567201811666140414120002
Price: $58