Antibiotic Releasing Biodegradable Scaffolds for Osteomyelitis
Manitha Nair and Amit Krishnan
Affiliation: Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Science & Research Center, Amrita Vishwa Vidyapeetham University, Cochin, Kerala 682041, India.
Osteomyelitis is characterized by progressive inflammatory bone degeneration. In the management of chronic
osteomyelitis, it is necessary to remove the infected bone tissue followed by implantation of an antibiotic releasing biomaterial
that can release antibiotic locally for long periods of time. The main carrier used in clinics for this application is polymethylmethacrylate
(PMMA) (Eg. Septopal beads). However, major drawback is the need of an additional surgery to
remove the beads after therapy, as PMMA is not biodegradable. This necessitates the requirement of biodegradable carrier
systems that can release antibiotics and simultaneously support debrided bone formation. This review summarizes biodegradable
carrier systems that have been reported for the localised treatment and prophylaxis of osteomyelitis.
Keywords: Bacterial internalization, biodegradable scaffolds, osteomyelitis, staphylococcus aureus.
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