Current Drug Delivery

Istvan Toth
School of Pharmacy,University of Queensland
Brisbane, 4072


Antibiotic Releasing Biodegradable Scaffolds for Osteomyelitis

Author(s): Manitha Nair and Amit Krishnan

Affiliation: Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Science & Research Center, Amrita Vishwa Vidyapeetham University, Cochin, Kerala 682041, India.

Graphical Abstract:


Osteomyelitis is characterized by progressive inflammatory bone degeneration. In the management of chronic osteomyelitis, it is necessary to remove the infected bone tissue followed by implantation of an antibiotic releasing biomaterial that can release antibiotic locally for long periods of time. The main carrier used in clinics for this application is polymethylmethacrylate (PMMA) (Eg. Septopal beads). However, major drawback is the need of an additional surgery to remove the beads after therapy, as PMMA is not biodegradable. This necessitates the requirement of biodegradable carrier systems that can release antibiotics and simultaneously support debrided bone formation. This review summarizes biodegradable carrier systems that have been reported for the localised treatment and prophylaxis of osteomyelitis.

Keywords: Bacterial internalization, biodegradable scaffolds, osteomyelitis, staphylococcus aureus.

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Article Details

Page: [687 - 700]
Pages: 14
DOI: 10.2174/1567201811666140414120002