Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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New Drugs for HDL-C Disorders: The Beginning

Author(s): MyNgan Duong, Stephen J. Nicholls.

Abstract:

For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the potential clinical utility of this therapeutic target. A number of classes of agents are currently under investigation with variable effects on HDL quantity and quality. These will be reviewed.

Keywords: Atherosclerosis, cardiovascular disease, HDL, lipids, risk factors.

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Article Details

VOLUME: 21
ISSUE: 25
Year: 2014
Page: [2947 - 2951]
Pages: 5
DOI: 10.2174/0929867321666140414104130
Price: $58