Gene therapy has potential in the treatment of human cancers. However, its clinical implication has only
achieved little success due to the lack of an efficient gene delivery system. A major hurdle in the current available
approaches is in the ability to transduce target tissues at very high efficiencies that ultimately lead to therapeutic levels of
transgene expression. This review outlines the characteristics and utilities of several available gene delivery systems,
including their advantages and drawbacks in the context of cancer treatment. A perspective of existing challenges and
future directions is also included.
Keywords: Cancer therapy, Gene therapy, Gene delivery, Liposomes, Nanoparticles, Non-viral vectors, Viral vectors.
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