Assessing the Validity of QSARs for Ready Biodegradability of Chemicals: An Applicability Domain Perspective

Author(s): Faizan Sahigara, Davide Ballabio, Roberto Todeschini, Viviana Consonni.

Journal Name:Current Computer-Aided Drug Design

Volume 10 , Issue 2 , 2014

Abstract:

Several classical and two recently proposed Applicability Domain (AD) approaches were implemented on a set of three classification models retrieved from a published study to assess the ready biodegradability of chemicals. Each model was associated with an optimal AD approach based on its ability to a) retain maximum test molecules within the model’s AD, b) be appropriate for the strategy used towards model development and c) show reasonably converging results with those derived with other AD approaches used. A decision criterion was also set to evaluate the AD of two consensus models that were developed in the original study. An overview of test molecules excluded from the AD of all the five biodegradability models was provided including an attempt to identify the major structural features and molecular descriptors possibly relevant in deciding upon their ready biodegradability. Apart from the test set, an overview of the results derived on the external validation set molecules was provided.

Keywords: Applicability domain, biodegradability, local-centred mahalanobis distance, model validation, QSAR.

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2014
Page: [137 - 147]
Pages: 11
DOI: 10.2174/1573409910666140410110241
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