Treatment of Insulin Resistance in the Neurodegeneration
Manuela Stefanelli, Antonio Martocchia, Elisabetta Adele De Marinis, Giulia Maria Falaschi, Gloria Romano, Maddalena Rufo and Paolo Falaschi
Affiliation: S.Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy.
The association between diabetes and neurodegenerative diseases is increasing with aging. Several common
mechanisms are involved in both these diseases.
The endothelial cells of the blood brain barrier, neurons and glia express typical and different receptors of the glucose metabolism
(glucose transporters, insulin receptors and glucagon-like peptide-1 receptors). The impairment in insulin
signaling leads to an impairment of neuronal function and increases neurodegeneration, and, conversely,
neurodegeneration causes a reduction of insulin signaling on neurons.
Increased detailed knowledge of common physiological processes opens up the opportunities for developing new
treatments that may prevent or reduce the onset of neurodegenerative diseases. The aim of the review is to discuss the potential
neuroprotective effects of the antidiabetic drugs. The article presents somepromising patents on the treatment of insulin
resistance in the neurodegeneration.
Keywords: Insulin resistance, neurodegeneration, glucagon-like peptide-1, incretins, insulin receptors.
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