Microwave-assisted Cycloaddition Reactions in Carbo- and Heterocyclic Chemistry

Author(s): Aziza Saber, Hamid Marzag, Rachid Benhida, Khalid Bougrin.

Journal Name: Current Organic Chemistry

Volume 18 , Issue 16 , 2014

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Abstract:

Recent developments in the microwave-assisted synthesis of carbo- and heterocyclicsystems are reviewed with the focus on diversity-oriented cycloaddition reactions. Ineed, these reactions represent one of the most important endeavors in chemistry and are of considerable interest in the synthesis of carbo-and heterocyclic compounds from simple unsaturated systems, and allow the creation of more than two bonds in one step. This review summarizes recent literature (2006-2013) on advances regarding [3+2], [4+2] and [2+2] cycloadditions including their miscellaneous version. Advantages of microwave dielectric heating are highlighted by comparison with conventional thermal conditions. In particular, we describe here the microwave effect, reaction media including solvent-free transformations and more ecological processes in the context of green and environmentally benign chemistry.

Keywords: [2+2] cycloaddition, 1, 3-dipolar cycloaddition, carbocycles, diels-alder, green catalysis, green chemistry, heterocycles, microwave synthesis.

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Article Details

VOLUME: 18
ISSUE: 16
Year: 2014
Page: [2139 - 2180]
Pages: 42
DOI: 10.2174/1385272819666140407213427
Price: $58

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