Abstract
Background: Oxidative damage of tissues and cellular components is a primary or secondary cause of many human diseases and is associated with the welfare and productivity of farm animals. Natural antioxidants have gained attention for the prevention of oxidative damage-related diseases.
Aim of the Study: To determine the effects of dietary supplementation with a natural polyphenol (verbascoside, VB) on the serum lipid profile, the hepatic functionality and oxidative status of jennies and their suckling foals.
Results: Supplementation with VB over 30 days decreased in jennies the serum levels of total cholesterol, LDL cholesterol, triglycerides, bilirubin, AST and ALT, and it increased the HDL cholesterol. As markers of the oxidative status, a decrease of ROMs and TBARs, and an increase in vitamin E levels were observed. Interestingly, the suckling foals showed the same trends in the blood parameters and oxidative status.
Conclusions: Supplementation with VB influenced the lipidic and hepatic profiles, and oxidative status of jennies and the suckling foals, and may represent a potentially novel strategy for improving the functional properties of donkey’s milk for human diet and for improving the welfare of young animals.
Keywords: Blood parameters, donkeys, milk, oxidative status, verbascoside.
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:Effects of Verbascoside Administration on the Blood Parameters and Oxidative Status in Jennies and Their Suckling Foals: Potential Improvement of Milk for Human Use
Volume: 14 Issue: 2
Author(s): Angela G. D'Alessandro, Donato Casamassima, Felicita Jirillo and Giovanni Martemucci
Affiliation:
Keywords: Blood parameters, donkeys, milk, oxidative status, verbascoside.
Abstract: Background: Oxidative damage of tissues and cellular components is a primary or secondary cause of many human diseases and is associated with the welfare and productivity of farm animals. Natural antioxidants have gained attention for the prevention of oxidative damage-related diseases.
Aim of the Study: To determine the effects of dietary supplementation with a natural polyphenol (verbascoside, VB) on the serum lipid profile, the hepatic functionality and oxidative status of jennies and their suckling foals.
Results: Supplementation with VB over 30 days decreased in jennies the serum levels of total cholesterol, LDL cholesterol, triglycerides, bilirubin, AST and ALT, and it increased the HDL cholesterol. As markers of the oxidative status, a decrease of ROMs and TBARs, and an increase in vitamin E levels were observed. Interestingly, the suckling foals showed the same trends in the blood parameters and oxidative status.
Conclusions: Supplementation with VB influenced the lipidic and hepatic profiles, and oxidative status of jennies and the suckling foals, and may represent a potentially novel strategy for improving the functional properties of donkey’s milk for human diet and for improving the welfare of young animals.
Export Options
About this article
Cite this article as:
D'Alessandro G. Angela, Casamassima Donato, Jirillo Felicita and Martemucci Giovanni, Effects of Verbascoside Administration on the Blood Parameters and Oxidative Status in Jennies and Their Suckling Foals: Potential Improvement of Milk for Human Use, Endocrine, Metabolic & Immune Disorders - Drug Targets 2014; 14 (2) . https://dx.doi.org/10.2174/1871530314666140407152347
DOI https://dx.doi.org/10.2174/1871530314666140407152347 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Current and Future Drugs for Appetite Regulation and Obesity Treatment
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Impact of Matrix Metalloproteinases on Atherosclerosis
Current Drug Targets Epidemiology and Etiology of Alzheimer’s disease: From Genetic to Non- Genetic Factors
Current Alzheimer Research The Role of Coronary Angioplasty in the Management of Patients with Stable Coronary Artery Disease
Cardiovascular & Hematological Disorders-Drug Targets Is there a Role for Cortisol in the Accumulation of Lipids in the Intima a Crucial Step of Atherogenesis?
Current Vascular Pharmacology Dietary Approaches and Alternative Therapies for Polycystic Ovary Syndrome
Current Nutrition & Food Science The Pleiotropic Effects of ARB in Vascular Endothelial Progenitor Cells
Current Vascular Pharmacology Targeting Cancer Stem Cell Lines as a New Treatment of Human Cancer
Recent Patents on Anti-Cancer Drug Discovery Current Problems with Non-Specific COX Inhibitors
Current Pharmaceutical Design Cardiac Specific Overexpression of hHole Attenuates Isoproterenol–Induced Hypertrophic Remodeling through Inhibition of Extracellular Signal-Regulated Kinases (ERKs) Signalling
Current Molecular Medicine Pleiotropic Effects of Statins - Clinical Evidence
Current Pharmaceutical Design Low Activity of Plasminogen Activator: A Common Feature of Non- Iatrogenic Comorbidities of Schizophrenia
CNS & Neurological Disorders - Drug Targets The Role of Dietary Fats in Hypertension, Obesity and Insulin Resistance: A Comparative Study of Animals and Humans in Fetal and Adult Life
Current Nutrition & Food Science Electroanalytical Methods for Determination of Calcium Channel Blockers
Current Analytical Chemistry Evaluation and Management of Asymptomatic Bradyarrhythmias
Current Cardiology Reviews Proposing a “Lipemic Index” As a Nutritional and Research Tool
Current Vascular Pharmacology Novel Inflammatory Markers in Hyperlipidemia: Clinical Implications
Current Medicinal Chemistry Antioxidant Treatment and Endothelial Dysfunction: Is it Time for Flavonoids?
Recent Patents on Cardiovascular Drug Discovery Novel Molecular Targets in the Treatment of Cardiac Hypertrophy
Recent Patents on Cardiovascular Drug Discovery The Effects of Medications Used for the Management of Dyslipidemia on Postprandial Lipemia
Current Medicinal Chemistry