Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Recent Developments on Thiourea Based Anticancer Chemotherapeutics

Author(s): Vikas Kumar, Swapandeep Singh Chimni.

Graphical Abstract:


Abstract:

The recent emergence of anticancer activity of thiourea derivatives have inspired the medicinal chemist to design and synthesize new thiourea derivatives. These thiourea based anticancer chemotherapeutics inhibit cancer propagation by acting as inhibitors of topoisomerase, protein tyrosine kinase, somatostatin agonists, sirtuins, and carbonic anhydrase (CA). This review summarizes the recent developments on the thiourea based anticancer chemotherapeutics.

Keywords: Anticancer chemotherapeutics, carbonic anhydrase (CA) inhibitors, protein tyrosine kinase inhibitors, sirtuins inhibitors, thiourea, somatostatin agonists, topoisomerase inhibitors.

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Article Details

VOLUME: 15
ISSUE: 2
Page: [163 - 175]
Pages: 13
DOI: 10.2174/1871520614666140407123526
Price: $58