Abstract
In recent years, our knowledge regarding the metabolism of melanoma has greatly advanced and consequently new therapeutic strategies are being developed. This review is focused on metabolic pathways contributing to melanoma proliferation, the influence of BRAF inhibitors on those metabolic pathways and finally a presentation of potential therapeutic strategies aimed at blocking metabolic signaling pathways and therefore melanoma development.
Keywords: Glycolysis, mitochondria, oxidative stress, warburg.
Current Cancer Drug Targets
Title:Metabolic Features of Melanoma: A Gold Mine of New Therapeutic Targets?
Volume: 14 Issue: 4
Author(s): Philippe Marchetti, Pierre Guerreschi, Jerome Kluza and Laurent Mortier
Affiliation:
Keywords: Glycolysis, mitochondria, oxidative stress, warburg.
Abstract: In recent years, our knowledge regarding the metabolism of melanoma has greatly advanced and consequently new therapeutic strategies are being developed. This review is focused on metabolic pathways contributing to melanoma proliferation, the influence of BRAF inhibitors on those metabolic pathways and finally a presentation of potential therapeutic strategies aimed at blocking metabolic signaling pathways and therefore melanoma development.
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Marchetti Philippe, Guerreschi Pierre, Kluza Jerome and Mortier Laurent, Metabolic Features of Melanoma: A Gold Mine of New Therapeutic Targets?, Current Cancer Drug Targets 2014; 14 (4) . https://dx.doi.org/10.2174/1568009614666140407113124
DOI https://dx.doi.org/10.2174/1568009614666140407113124 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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