Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Metabolic Features of Melanoma: A Gold Mine of New Therapeutic Targets?

Author(s): Philippe Marchetti, Pierre Guerreschi, Jerome Kluza and Laurent Mortier

Affiliation: INSERM U 837 Faculte de Medecine, 1, place Verdun F- 59045 Lille Cedex, France.

Keywords: Glycolysis, mitochondria, oxidative stress, warburg.

Abstract:

In recent years, our knowledge regarding the metabolism of melanoma has greatly advanced and consequently new therapeutic strategies are being developed. This review is focused on metabolic pathways contributing to melanoma proliferation, the influence of BRAF inhibitors on those metabolic pathways and finally a presentation of potential therapeutic strategies aimed at blocking metabolic signaling pathways and therefore melanoma development.

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Article Details

VOLUME: 14
ISSUE: 4
Page: [357 - 370]
Pages: 14
DOI: 10.2174/1568009614666140407113124