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Endocrine, Metabolic & Immune Disorders-Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)
ISSN (Print): 1871-5303
ISSN (Online): 2212-3873
VOLUME: 14
ISSUE: 2
DOI: 10.2174/1871530314666140407111410      Price:  $58









Amiodarone-Induced SIADH: Two Cases Report

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Author(s): Michele Iovino, Nicola Iovine, Antonio Petrosino, Brunella Licchelli, Vito A. Giagulli, Massimo Iacoviello, Edoardo Guastamacchia and Vincenzo Triggiani
Pages 123-125 (3)
Abstract:
Amiodarone-induced SIADH is a rare but serious side effect of this drug. We report two cases of mild hyponatremia, observed in the last five years, and discuss the role played by age, sex and dose of amiodarone as well as the influence that this molecule may have on aquaporin-2 water channel expression in the renal collecting ducts.
Keywords:
Amiodarone, aquaporin-2, hyponatremia, hypothyroidism, renal collecting ducts, SIADH.
Affiliation:
Endocrinology and Metabolic Diseases, Eboli Hospital, Salerno, Italy.