Endocrine, Metabolic & Immune Disorders-Drug Targets

(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Emilio Jirillo  
Universitá degli Studi di Bari
Dipartimento di Clinica Medica
Immunologia e Malattie Infettive
Sezione di Microbiologia e Immunologia
Piazza Giulio Cesare-Policlinico
Bari
Italy

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Amiodarone-Induced SIADH: Two Cases Report

Author(s): Michele Iovino, Nicola Iovine, Antonio Petrosino, Brunella Licchelli, Vito A. Giagulli, Massimo Iacoviello, Edoardo Guastamacchia and Vincenzo Triggiani

Affiliation: Endocrinology and Metabolic Diseases, Eboli Hospital, Salerno, Italy.

Keywords: Amiodarone, aquaporin-2, hyponatremia, hypothyroidism, renal collecting ducts, SIADH.

Abstract:

Amiodarone-induced SIADH is a rare but serious side effect of this drug. We report two cases of mild hyponatremia, observed in the last five years, and discuss the role played by age, sex and dose of amiodarone as well as the influence that this molecule may have on aquaporin-2 water channel expression in the renal collecting ducts.

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Article Details

VOLUME: 14
ISSUE: 2
Page: [123 - 125]
Pages: 3
DOI: 10.2174/1871530314666140407111410