Mechanically Activated Solid-State Synthesis of Phenylhydrazone Derivatives via High-Speed Ball Milling
Xingyi Zhu, Yuanyuan Chen, Yuhe Chen, Jue Wang and Weike Su
Affiliation: Key Laboratory of Pharmaceutical Engineering (Ministry of Education), Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P.R. China.
A series of phenylhydrazone derivatives was synthesized from arenediazonium tetrafluoroborates and active
methylene compounds under high-speed ball milling. The reaction occurred in the absence of the solvent and products
were obtained in good yield within short reaction times (no more than 30 min).
Keywords: Ball milling, solid-state synthesis, phenylhydrazones, arenediazonium tetrafluoroborates, active methylene compounds.
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