Letters in Organic Chemistry

Miguel Yus  
Universidad de Alicante Apdo
Alicante
Spain

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Mechanically Activated Solid-State Synthesis of Phenylhydrazone Derivatives via High-Speed Ball Milling

Author(s): Xingyi Zhu, Yuanyuan Chen, Yuhe Chen, Jue Wang and Weike Su

Affiliation: Key Laboratory of Pharmaceutical Engineering (Ministry of Education), Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P.R. China.

Keywords: Ball milling, solid-state synthesis, phenylhydrazones, arenediazonium tetrafluoroborates, active methylene compounds.

Graphical Abstract:


Abstract:

A series of phenylhydrazone derivatives was synthesized from arenediazonium tetrafluoroborates and active methylene compounds under high-speed ball milling. The reaction occurred in the absence of the solvent and products were obtained in good yield within short reaction times (no more than 30 min).

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Article Details

VOLUME: 11
ISSUE: 8
Page: [621 - 626]
Pages: 6
DOI: 10.2174/1570178611999140404111411