Mechanically Activated Solid-State Synthesis of Phenylhydrazone Derivatives via High-Speed Ball Milling
Xingyi Zhu, Yuanyuan Chen, Yuhe Chen, Jue Wang and Weike Su
Affiliation: Key Laboratory of Pharmaceutical Engineering (Ministry of Education), Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P.R. China.
Keywords: Ball milling, solid-state synthesis, phenylhydrazones, arenediazonium tetrafluoroborates, active methylene compounds.
A series of phenylhydrazone derivatives was synthesized from arenediazonium tetrafluoroborates and active
methylene compounds under high-speed ball milling. The reaction occurred in the absence of the solvent and products
were obtained in good yield within short reaction times (no more than 30 min).
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