Proteomics, and Metabolomics: Magnetic Resonance Spectroscopy for the Presurgical Screening of Thyroid Nodules
Michele N. Minuto, Laetitia Shintu and Stefano Caldarelli
Affiliation: Department of Surgical Sciences (DISC), University of Genoa, Genoa, Italy.
Keywords: Cytology, Fine-needle aspiration, High-resolution magic-angle-spinning, Magnetic resonance spectroscopy, Metabolomics,
Proteomics, Thyroid nodules, Thyroid cancer.
We review the progress and state-of-the-art applications of studies in Magnetic Resonance Spectroscopy
(MRS) and Imaging as an aid for diagnosis of thyroid lesions of different nature, especially focusing our attention to those
lesions that are cytologically undetermined. It appears that the high-resolution of High-Resolution Magic-Angle-Spinning
(HRMAS) MRS improves the overall accuracy of the analysis of thyroid lesions to a point that a significant improvement
in the diagnosis of cytologically undetermined lesions can be expected. This analysis, in the meantime, allows a more precise
comprehension of the alterations in the metabolic pathways induced by the development of the different tumors. Although
these results are promising, at the moment, a clinical application of the method to the common workup of thyroid
nodules cannot be used, due to both the limitation in the availability of this technology and the wide range of techniques,
that are not uniformly used. The coming future will certainly see a wider application of these methods to the clinical practice
in patients affected with thyroid nodules and various other neoplastic diseases.
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