Current Angiogenesis

Guo-Chang Fan , PHD
Dept. of Pharmacology and Cell Biophysics
University of Cincinnati College of Medicine
Cincinnati
USA

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Targeting Angiogenesis in the Treatment of Multiple

Author(s): Najib Dally and Elizabeth Eshel

Affiliation: Hematology Institute, Ziv Medical Center affiliated with the Faculty of Medicine in Zefat, Bar Ilan University, Zefat, Israel.

Keywords: Angiogenesis inhibitors, anti angiogenetic agents, anti-angiogenic effects, immunomodulation, multiple myeloma.

Graphical Abstract:


Abstract:

Multiple Myeloma (MM) remains an incurable disease. Scientific understanding of the biology and influence of the microenvironment in disease progression and outcome has led to treatment improvements by targeting angiogenesis. Reviews of the underlying biology and meta-analyses of the clinical data tend to be mutually exclusive. This minireview highlights important data regarding angiogenesis in MM as well as the drugs currently used to target angiogenesis in its treatment.

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Article Details

VOLUME: 3
ISSUE: 1
Page: [39 - 47]
Pages: 9
DOI: 10.2174/2211552802666140404003016